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lncR-GAS5 upregulates the splicing factor to impair endothelial autophagy, leading to atherogenesis

Frontiers of Medicine 2023, Volume 17, Issue 2, Pages 317-329 doi: 10.1007/s11684-022-0931-4

Abstract: Moreover, serine/arginine-rich splicing factor 10 (SRSF10i>) knockdown increased the LC3II/LC3IMechanistically, lncR-GAS5 regulated the downstream splicing factor SRSF10i> to impair autophagyin the endothelium, which was reversed by the knockdown of SRSF10i>.SRSF10i>.Thus, miR-193-5p/SRSF10i> may serve as a novel treatment target for atherosclerosis.

Keywords： lncR-GAS5 miR-193-5p splicing factor SRSF10i> autophagy atherogenesis

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High frequency of alternative splicing variants of the oncogene in neuroendocrine tumors of the pancreas

Frontiers of Medicine Pages 907-923 doi: 10.1007/s11684-023-1009-7

Abstract: Here, based on the analysis of the splicing variants of an oncogene Focal Adhesion Kinasei> (that Box 6/Box 7-containing FAKi> variants (FAKi>^6/7i>) were observed in 7We further tested FAKi> splicing variants in breast neuroendocrine carcinoma (BrNECs), and foundWe explored the underlying mechanisms and found that a splicing factor serine/arginine repetitive matrixbreast tumors, which promoted the formation of FAKi>^6/7i> in cells.

Keywords： FAKi>^6/7i> SRRM4 neuroendocrine neoplasms pancreas breast

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NES1i>/KLK10i> and hNISi> gene therapy enhanced iodine-131 internal radiation in PC3 proliferation

Jiajia Hu, Wenbin Shen, Qian Qu, Xiaochun Fei, Ying Miao, Xinyun Huang, Jiajun Liu, Yingli Wu, Biao Li

Frontiers of Medicine 2019, Volume 13, Issue 6, Pages 646-657 doi: 10.1007/s11684-018-0643-y

Abstract: , we supposed to have an “enhanced firepower” effect by combining overexpressed gene therapy and Itomography/computed tomography (micro-PET/CT) imaging showed that the combined gene therapy and Ithat via inhibition of expression, overexpressed might enhance the effect of radiation therapy of I

Keywords： androgen-independent prostate cancer normal epithelial cell-specific 1/kallikrein 10 sodium/iodide symporter

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MicroRNA-148b promotes proliferation of hair follicle cells by targeting

Wanbao YANG,Qinqun LI,Bo SU,Mei YU

Frontiers of Agricultural Science and Engineering 2016, Volume 3, Issue 1, Pages 72-80 doi: 10.15302/J-FASE-2016089

Abstract: Furthermore, transcript factor nuclear factor of activated T cells type 5 ( ) and were predicted to

Keywords： miR-148b hair follicle proliferation NFAT5i> Wnt10bi>

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NO hydrogenation to NH over FeCu/TiO catalyst with improved activity

Frontiers of Chemical Science and Engineering 2023, Volume 17, Issue 12, Pages 1973-1985 doi: 10.1007/s11705-023-2364-2

Abstract: Notably, the optimized 10Fe-8Cu/TiO₂ catalyst exhibited exceptional catalytic performanceWe employed in situi> diffuse reflectance Fourier transform infrared spectroscopy and conducted

Keywords： NO hydrogenation synthetic ammonia 10Fe-xi>Cu/TiO₂ high selectivity

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Prokaryotic expression and bioactivity analysis of growth hormone and insulin-like growth factor-I from

Xu Yongjiang,Zang Kun,Liu Xuezhou,Shi Bao and Chen Shengyi

Strategic Study of CAE 2015, Volume 17, Issue 1, Pages 67-73

Abstract:

The mature peptide domain of insulin-like growth factor-I from Platichthys stellatus were amplifiedfragment was subcloned into the prokaryotic expression vector pET-28a to successfully construct IGF-I/The obtained IGF-I polypeptide expressed in form of inclusion bodies with molecular weight of 12.1 kDTherefore， the IGF-I prokaryotic expression system was successfully constructed in the present studyand biologically active IGF-I fusion protein was obtained.

Keywords： Platichthys stellatus； insulin-like growth factor-I； prokaryotic expression； bioactivity

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Discovery of Kaempferol, a Novel ADAM10 Inhibitor, as a Potential Treatment for Staphylococcus aureusi> Infection Article

Tingting Wang, Jianfeng Wang, Xiangzhu Xu, Fan Jiang, Hongfa Lv, Qinghui Qi, Can Zhang, Qianghua Lv, Xuming Deng

Engineering 2023, Volume 28, Issue 9, Pages 206-221 doi: 10.1016/j.eng.2023.03.006

Abstract: indispensable specific cellular receptor for α-toxin (Hla), a-disintegrin and metalloproteinase 10(ADAM10) is exploited to accelerate S. aureus infection through diverse mechanisms.The extraordinary contribution of ADAM10 to S. aureus pathogenesis renders it an attractiveOur study is the first to demonstrate the indispensable role of ADAM10 in S. aureus-inducednecroptosis, and it enhances our knowledge of the role of ADAM10 in S. aureus infection.

Keywords： Host-directed therapy Kaempferol ADAM10 inhibitor Staphylococcus aureus infection Barrier disruption

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carcinoma progression by repressing translation through the interaction with eukaryotic initiation factorprogression by repressing translation through the interaction with eukaryotic initiation factor 4A-I

Frontiers of Medicine 2023, Volume 17, Issue 3, Pages 476-492 doi: 10.1007/s11684-022-0966-6

Abstract: In HCC cells, 5′-tiRNA-Gln overexpression impaired the proliferation, migration, and invasion in vitroi> and in vivoi>, while 5′-tiRNA-Gln knockdown yielded opposite results. 5′-tiRNA-Gln exertedits function by binding eukaryotic initiation factor 4A-I (EIF4A1), which unwinds complex RNA secondary

Keywords： EIF4A1 G-quadruplex hepatocellular carcinoma tRNA-derived small RNA translation initiation

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Bacteria-mediated tumor-targeted delivery of tumstatin (54-132) significantly suppresses tumor growth in mouse model by inhibiting angiogenesis and promoting apoptosis

Frontiers of Medicine 2022, Volume 16, Issue 6, Pages 873-882 doi: 10.1007/s11684-022-0925-2

Abstract: VNP20009, an attenuated Salmonella typhimuriumi> strain, preferentially accumulates in the hypoxicwith VNP-Tum5 effectively suppressed tumor growth and prolonged survival in the mouse model of B16F10exhibited a higher efficacy in inhibiting the proliferation and inducing the necrosis and apoptosis of B16F10cells in vitroi> and in vivoi> compared with VNP (control).VNP-Tum5 downregulated the expression of anti-vascular endothelial growth factor A, platelet endothelial

Keywords： Salmonellai> VNP20009 tumstatin B16F10 melanoma apoptosis angiogenesis

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DDB1- and CUL4-associated factor 8 plays a critical role in spermatogenesis

Xiuli Zhang, Zhizhou Xia, Xingyu Lv, Donghe Li, Mingzhu Liu, Ruihong Zhang, Tong Ji, Ping Liu, Ruibao Ren

Frontiers of Medicine 2021, Volume 15, Issue 2, Pages 302-312 doi: 10.1007/s11684-021-0851-8

Abstract: DDB1- and CUL4-associated factor 8 (DCAF8) is a WD40 repeat-containing protein, which serves as a substrate

Keywords： Dcaf8i> male infertility spermatogenesis

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Heuristic solution using decision tree model for enhanced XML schema matching of bridge structural calculation documents

Sang I. PARK, Sang-Ho LEE

Frontiers of Structural and Civil Engineering 2020, Volume 14, Issue 6, Pages 1403-1417 doi: 10.1007/s11709-020-0666-8

Abstract: Research on the quality of data in a structural calculation document (SCD) is lacking, although the SCD of a bridge is used as an essential reference during the entire lifecycle of the facility. XML Schema matching enables qualitative improvement of the stored data. This study aimed to enhance the applicability of XML Schema matching, which improves the speed and quality of information stored in bridge SCDs. First, the authors proposed a method of reducing the computing time for the schema matching of bridge SCDs. The computing speed of schema matching was increased by 13 to 1800 times by reducing the checking process of the correlations. Second, the authors developed a heuristic solution for selecting the optimal weight factors used in the matching process to maintain a high accuracy by introducing a decision tree. The decision tree model was built using the content elements stored in the SCD, design companies, bridge types, and weight factors as input variables, and the matching accuracy as the target variable. The inverse-calculation method was applied to extract the weight factors from the decision tree model for high-accuracy schema matching results.

Keywords： structural calculation document bridge structure XML Schema matching weight factor data mining decision

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Development of a new method for RMR and Q classification method to optimize support system in tunneling

Asghar RAHMATI,Lohrasb FARAMARZI,Manouchehr SANEI

Frontiers of Structural and Civil Engineering 2014, Volume 8, Issue 4, Pages 448-455 doi: 10.1007/s11709-014-0262-x

Abstract: Rock mass classification system is very suitable for various engineering design and stability analysis. classification method is confirmed by Japan Highway Public Corporation that this method can figure out either strength or deformability of rock mass, further appropriating the amount of rock bolts, thickness of shotcrete, and size of pitch of steel ribs just after the blasting procedure. Based on these advantages of method, in this study, according to data of five deep and long tunnels in Iran, two equations for estimating the value of method from and classification systems were developed. These equations as a new method were able to optimize the support system for and classification systems. From classification and its application in these case studies, it is pointed out that the method for the design of support systems in underground working is more reliable than the and classification systems.

Keywords： JHi> classification Qi> and RMRi> classification new method

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The Potential Role of Powdery Mildew-Resistance Gene Pm40i> in Chinese Wheat-Breeding Programs inthe Post-Pm21i> Era Perspective

Shengwen Tang,Yuting Hu,Shengfu Zhong,Peigao Luo

Engineering 2018, Volume 4, Issue 4, Pages 500-506 doi: 10.1016/j.eng.2018.06.004

Abstract:

Powdery mildew, which is caused by Blumeria graminis f. sp. tritici (Bgt), is an important leaf disease that affects wheat yield. Powdery mildew-resistance (Pm) gene Pm21 was first transferred into wheat in the 1980s, by translocating the Heuchera villosa chromosome arm 6VS to the wheat chromosome arm 6AL (6VS·6AL). Recently, new Bgt isolates that are virulent to Pm21 have been identified in some wheat fields, indicating that wheat breeders should be aware of the risk of deploying Pm21, although pathological details regarding these virulent isolates still remain to be discovered. Pm40 was identified and mapped on the wheat chromosome arm 7BS from several wheat lines developed from the progenies of a wild cross between wheat and Thinopyrum intermedium. Pm40 offers a broad spectrum of resistance to Bgt, which suggests that it is likely to provide potentially durable resistance. Cytological methods did not detect any large alien chromosomal segment in the wheat lines carrying Pm40. Lines with Pm40 and promising agronomical traits have been released by several wheat-breeding programs in the past several years. Therefore, we believe that Pm40 will play a role in powdery mildew-resistance wheat breeding after Pm21 resistance is overcome by Bgt isolates. In addition, both Pm21 and Pm40 were derived from alien species, suggesting that the resistance genes derived from alien species are potentially more durable or effective than those identified from wheat.

Keywords： Wheat Powdery mildew Pm21i> Pm40i> Alien species Native resistance

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Identification of pakchoi cultivars with low cadmium accumulation and soil factors that affect their cadmium uptake and translocation

Lin WANG,Yingming XU,Yuebing SUN,Xuefeng LIANG,Dasong LIN

Frontiers of Environmental Science & Engineering 2014, Volume 8, Issue 6, Pages 877-887 doi: 10.1007/s11783-014-0676-7

Abstract: Results also showed that soil phosphorus availability was the most important soil factor in the Cd accumulation

Keywords： pakchoi (Brassica chinensisi> L.) cadmium contamination low-cadmium-accumulating cultivar (LCAC) genotype variation soil factor translocation

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NiFeRuO_xi> nanosheets on Ni foam as an electrocatalyst for efficient

Frontiers of Chemical Science and Engineering 2023, Volume 17, Issue 11, Pages 1698-1706 doi: 10.1007/s11705-023-2334-8

Abstract: The electrocatalyst NiFeRuO_xi>/NF, comprised of NiFeRuO_xi> nanosheetsNiFeRuO_xi>/NF displays high electrocatalytic activity and stability for overall alkalineseawater splitting: 98 mV@ 10 mA∙cm⁻² in hydrogen evolution reaction, 318 mV@ 50 mA∙cm⁻² in oxygen evolution reaction, and a cell voltage of 1.53 V@ 10 mA∙cm⁻², as wellfactor for enhancement of bifunctional performances.

Keywords： NiFeRuO_xi> nanosheets Ni foam electrocatalysis overall seawater splitting solar-driven

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Title Author Date Type Operation

lncR-GAS5 upregulates the splicing factor to impair endothelial autophagy, leading to atherogenesis

Journal Article

High frequency of alternative splicing variants of the oncogene in neuroendocrine tumors of the pancreas

Journal Article

NES1i>/KLK10i> and hNISi> gene therapy enhanced iodine-131 internal radiation in PC3 proliferation

Jiajia Hu, Wenbin Shen, Qian Qu, Xiaochun Fei, Ying Miao, Xinyun Huang, Jiajun Liu, Yingli Wu, Biao Li

Journal Article

MicroRNA-148b promotes proliferation of hair follicle cells by targeting

Wanbao YANG,Qinqun LI,Bo SU,Mei YU

Journal Article

NO hydrogenation to NH over FeCu/TiO catalyst with improved activity

Journal Article

Prokaryotic expression and bioactivity analysis of growth hormone and insulin-like growth factor-I from

Xu Yongjiang,Zang Kun,Liu Xuezhou,Shi Bao and Chen Shengyi

Journal Article

Discovery of Kaempferol, a Novel ADAM10 Inhibitor, as a Potential Treatment for Staphylococcus aureusi> Infection

Tingting Wang, Jianfeng Wang, Xiangzhu Xu, Fan Jiang, Hongfa Lv, Qinghui Qi, Can Zhang, Qianghua Lv, Xuming Deng

Journal Article

Bacteria-mediated tumor-targeted delivery of tumstatin (54-132) significantly suppresses tumor growth in mouse model by inhibiting angiogenesis and promoting apoptosis

Journal Article

DDB1- and CUL4-associated factor 8 plays a critical role in spermatogenesis

Xiuli Zhang, Zhizhou Xia, Xingyu Lv, Donghe Li, Mingzhu Liu, Ruihong Zhang, Tong Ji, Ping Liu, Ruibao Ren

Journal Article

Heuristic solution using decision tree model for enhanced XML schema matching of bridge structural calculation documents

Sang I. PARK, Sang-Ho LEE

Journal Article

Development of a new method for RMR and Q classification method to optimize support system in tunneling

Asghar RAHMATI,Lohrasb FARAMARZI,Manouchehr SANEI

Journal Article

The Potential Role of Powdery Mildew-Resistance Gene Pm40i> in Chinese Wheat-Breeding Programs inthe Post-Pm21i> Era

Shengwen Tang,Yuting Hu,Shengfu Zhong,Peigao Luo

Journal Article

Identification of pakchoi cultivars with low cadmium accumulation and soil factors that affect their cadmium uptake and translocation

Lin WANG,Yingming XU,Yuebing SUN,Xuefeng LIANG,Dasong LIN

Journal Article

NiFeRuO_xi> nanosheets on Ni foam as an electrocatalyst for efficient

Journal Article

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